کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1313785 1499322 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Catalytic asymmetric conjugate addition of α-fluoro β-ketophosphonates to nitroalkenes in the presence of nickel complexes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Catalytic asymmetric conjugate addition of α-fluoro β-ketophosphonates to nitroalkenes in the presence of nickel complexes
چکیده انگلیسی


• This is the first example of catalytic conjugate addition of α-fluoro β-ketophosphonates to nitroalkenes using chiral transition metal.
• Excellent diastereoselectivities (10–50:1), enantioselectivities (93–99% ee), and high yields were observed.
• This reaction conditions is mild and stable in air- and moisture.
• This synthetic method is highly efficient catalytic system (1 mol% of catalyst).

The catalytic enantioselective conjugate addition reaction of α-fluoro β-ketophosphonates to nitroalkenes promoted by chiral nickel complexes is described. Treatment of α-fluoro β-ketophosphonates with nitroalkenes under mild reaction conditions afforded the corresponding Michael adducts containing fluorinated quaternary stereogenic center with excellent enantioselectivity (up to >99% ee).

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Fluorine Chemistry - Volume 178, October 2015, Pages 40–46
نویسندگان
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