کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1313941 1499324 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An approach to (4-fluoroalkyl-1-alkyl-1H-pyrazol-3-yl)methylamines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
An approach to (4-fluoroalkyl-1-alkyl-1H-pyrazol-3-yl)methylamines
چکیده انگلیسی

An approach to the synthesis (4-di- and -trifluoroalkyl-1-alkyl-1H-pyrazol-3-yl)methylamines – promising building blocks for drug discovery and medicinal chemistry is described. The key step of the reaction sequence is fluorination of the corresponding non-symmetric trisubstituted pyrazole derivatives bearing phtalimide moiety with diethylaminosulfur trifluoride or sulfur tetrafluoride. The title compounds are obtained in 5–6 steps from the commonly available materials and 35–36% overall yields.

Synthesis of fluorinated non-symmetric polysubstituted pyrazole building blocks is described.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Fluorine Chemistry - Volume 176, August 2015, Pages 78–81
نویسندگان
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