کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1314037 | 1499359 | 2012 | 5 صفحه PDF | دانلود رایگان |
A highly efficient one-pot three-component regioselective synthesis of 2-amino-3-cyano-4H-chromene and tetrahydrobenzo[b]pyran derivatives has been developed by annulation of aldehydes, malononitrile, and resorcinol or dimedone under reflux conditions in 2,2,2-trifluoroethanol without the use of a catalyst or any other additive.
2-Amino-4H-chromene and tetrahydrobenzo[b]pyran derivatives were synthesized in excellent yield in 2,2,2-trifluoroethanol.Figure optionsDownload as PowerPoint slideHighlights
► In this study we examine the TFE as a new recyclable medium.
► 2-Amino-4H-chromene and tetrahydrobenzo[b]pyran were synthesized in trifluoroethanol.
► This method has the ability to tolerate a wide variety of substitutions.
► TFE was easily recovered.
Journal: Journal of Fluorine Chemistry - Volume 141, September 2012, Pages 11–15