Microwave promoted one-pot preparation of fluorinated propargylamines and their chemical transformation

A series of fluorinated propargylamines have been synthesized from the one-pot three-component reaction of fluorobenzaldehyde, aniline and phenylacetylene under solvent-free and microwave irradiation. The fluorinated propargylamines were then further transformed to chalcones or quinoline derivatives respectively depending on the different structures of propargylamines.

A series of fluorinated propargylamines have been synthesized from the one-pot three-component reaction of fluorobenzaldehyde, aniline and phenylacetylene under solvent-free and microwave irradiation. The fluorinated propargylamines were then further transformed to chalcones or quinoline derivatives respectively depending on the different structures of propargylamines.Figure optionsDownload as PowerPoint slideHighlights
► A one-pot solvent-free microwave irradiation reaction was investigated.
► A series of fluorinated propargylamines have been synthesized.
► The products were further transformed to chalcones or quinolines.
► The possible mechanism was proposed.