One-pot preparation of fluorinated propargylamines under microwave irradiation and solvent-free conditions

A facile one-pot method has been developed for the synthesis of fluorine-containing propargylamines by a three-component coupling of fluorinated aldehydes, amines, and alkynes, in the presence of copper (I) chloride under microwave irradiation and solvent-free condition. This process is an efficient alternative to traditional thermal reaction. All new compounds are fully characterized by spectral methods.

A facile one-pot method has been developed for this A3 coupling reaction to gain series new fluorinated propargylamines under microwave irradiation and solvent-free condition.Figure optionsDownload as PowerPoint slide