کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1314540 | 975973 | 2010 | 5 صفحه PDF | دانلود رایگان |

The cobalt-catalysed methoxycarbonylation of polysubstituted bromo,fluoro- and chloro,fluorobenzenes and 1,2,4-trichlorobenzene with emphasis on the chemo- and regio-selectivity of the reaction is described. The structures of isolated products of 1,4-dichloro-2-fluorobenzene carbonylation were determined by single-crystal X-ray diffraction. The fact that the fluorine substituents in the studied compounds remain intact indicates in favor of the anion-radical activation of aryl halides by a cobalt catalyst. For the first time, a universal method of preparation of the various fluorobenzoic acid derivatives from available raw materials with a good yield has been elaborated.
The high selectivity of cobalt-catalysed carbonylation of mixed aryl halides (bromo,fluoro- and chloro,fluorobenzenes) and 1,2,4-trichlorobenzene is demonstrated and explained by anion-radical mechanism of aryl halides activation by modified cobalt carbonyl complex. It allows using this effective procedure as a universal method for synthesis of fluorinated benzoic acids.Figure optionsDownload as PowerPoint slide
Journal: Journal of Fluorine Chemistry - Volume 131, Issue 1, January 2010, Pages 81–85