Preparation of fluorinated biaryls through direct palladium-catalyzed coupling of polyfluoroarenes with aryltrifluoroborates

• A direct Pd-catalyzed coupling of polyfluoroarenes with aryltrifluoroborates to afford fluorinated biaryls has been developed.
• This reaction proceeds under mild conditions for the CH bond activation.
• A wide range of important functional groups are compatible with this reaction.

The direct palladium-catalyzed coupling of polyfluoroarenes with aryltrifluoroborates gave the desired products of fluorinated biaryls in good to excellent yields. A diverse set of important functional groups including methoxy, aldehyde, ester, nitro and halide can be well tolerated in the protocol.

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