کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1314611 | 975978 | 2008 | 5 صفحه PDF | دانلود رایگان |

An amphiphilic γ-cyclodextrin, selectively functionalized with perfluorobutanoyl group, octakis(6-O-perfluorobutanoyl)-γ-cyclodextrin (γ-CyD-F), was investigated as a potential sustained release carrier for hydrophilic drugs, taking molsidomine (MOL) as a model drug. Supercritical carbon dioxide, an environmentally benign solvent, was used for the preparation of MOL/γ-CyD-F inclusion complexes. The molecular encapsulation of MOL by the amphiphilic cyclodextrin was confirmed by differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD) studies. Additionally, 1H NMR spectroscopy was used to investigate the inclusion mode of drug with the γ-CyD-F. The in-vitro release of MOL from the peanut oil suspensions into aqueous phase was found to be significantly retarded by the complexation with γ-CyD-F, mainly due to the hydrophobic properties associated with the γ-CyD-F.
An amphiphilic cyclodextrin, modified with fluoroalkyl ester groups substituted at the primary rim of the macrocycle, was investigated for its potential use as a controlled release carrier for hydrophilic drugs. Host–guest inclusion complexes were prepared using a “green” solvent supercritical carbon dioxide.Figure optionsDownload as PowerPoint slide
Journal: Journal of Fluorine Chemistry - Volume 129, Issue 12, December 2008, Pages 1162–1166