Synthesis of polyfluorinated ortho-alkynylanilines

A series of polyfluorinated ortho-alkynylanilines – the versatile building blocks for diverse polyfluorobenzo azaheterocycles – have been synthesized by the Sonogashira reaction of polyfluorinated ortho-iodanilines with terminal alkynes.

A series of polyfluorinated ortho-alkynylanilines have been synthesized by the Sonogashira reaction of polyfluorinated ortho-iodanilines with terminal alkynes.Figure optionsDownload as PowerPoint slideHighlights
► Polyfluoroanilines ortho iodination.
► Sonogashira reaction of polyfluorinated ortho-iodanilines with terminal alkynes.
► Synthesis of 22 polyfluorinated ortho-alkynylanilines.