An efficient synthesis of 2-trifluoromethyl quinolines via gold-catalyzed cyclization of trifluoromethylated propargylamines

A highly efficient cyclization reaction of trifluoromethylated propargylamines leading to 2-trifluoromethyl-4-aryl quinolines was developed by using gold(I) as a catalyst under extremely mild conditions.

A highly efficient cyclization reaction of trifluoromethylated propargylamines leading to 2-trifluoromethyl-4-aryl quinolines was developed by using gold(I) as a catalyst under extremely mild conditions.Figure optionsDownload as PowerPoint slideHighlights
► Gold-catalyzed cyclization of trifluoromethylated propargylamines.
► Various 1-trifluoromethylpropargylamines are viable substrates.
► The reaction mechanism is suggested to involve cyclization-oxidation.