Functional tetrahydroquinoxalines from perfluoroaromatic precursors

A short series of bromo- and nitro-polyfluorobenzene derivatives gave the corresponding tetrahydroquinoxaline systems upon reaction with N,N′-dimethylethylene diamine. This annelation strategy gives useful quantities of functionalised tetrahydroquinoxaline systems which may be interesting scaffolds for the drug discovery arena.

Polyfluorobenzene derivatives gave tetrahydroquinoxaline systems upon reaction with N,N′-dimethylethylene diamine.Figure optionsDownload as PowerPoint slide