Keywords: جایگزینی معطر Nucleophilic; Primary sulfonamide; Electron-withdrawing group; Nucleophilic aromatic substitution; SMILES rearrangement; Reactivity-matched substrates; Carbonic anhydrase inhibitors; Isoform-selectivity;
مقالات ISI جایگزینی معطر Nucleophilic (ترجمه نشده)
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Keywords: جایگزینی معطر Nucleophilic; Active pharmaceutical ingredients; Continuous pharmaceutical manufacturing; Intensified reactors; Optimization; Nucleophilic aromatic substitution; Elementary process functions;
Keywords: جایگزینی معطر Nucleophilic; Flow chemistry; High-temperature reactions; Nucleophilic aromatic substitution;
Keywords: جایگزینی معطر Nucleophilic; 1,2,5,6-Tetrahydropyridines; Ring-closing metathesis; Nucleophilic aromatic substitution; Muscarinic receptor agonists; Aziridines;
Keywords: جایگزینی معطر Nucleophilic; Reactivity ratios; Nucleophilic aromatic substitution; Meta activation;
Keywords: جایگزینی معطر Nucleophilic; H/D exchange; Nucleophilic aromatic substitution; Stereochemistry; Catalysis; Reactive intermediates; Solution chemistry and electrospray ionization;
Keywords: جایگزینی معطر Nucleophilic; Nucleophilic aromatic substitution; 2-Imidazolylpyridine; Solvent free synthesis; Metal free coupling;
Keywords: جایگزینی معطر Nucleophilic; Thiols; Nucleophilic aromatic substitution; Nucleoside analogs; Purine derivatives;
A Mitsunobu reaction to functionalized cyclic and bicyclic N-arylamines
Keywords: جایگزینی معطر Nucleophilic; Mitsunobu; Cyclodehydration; Nucleophilic aromatic substitution; Intramolecular; Cyclisation;
Novel approach towards 3,7-disubstituted 1,6-naphthyridin-4(1H)-ones exploiting cross-coupling and SNAr reactions of a dihalogenated compound
Keywords: جایگزینی معطر Nucleophilic; 1,6-Naphthyridin-4(1H)-ones; Suzuki-Miyaura reaction; Buchwald-Hartwig amination; Nucleophilic aromatic substitution; Halodecarboxylation;
One-pot synthesis of substituted indolo[1,2-a]quinolines under transition-metal-free conditions
Keywords: جایگزینی معطر Nucleophilic; One-pot synthesis; Transition-metal-free synthesis; Indolo[1,2-a]quinoline; Nucleophilic aromatic substitution; Knoevenagel condensation;
Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4
Keywords: جایگزینی معطر Nucleophilic; ABC; Activated B Cell-like; BTK; Bruton's Tyrosine Kinase; CD79; Cluster of Differentiation 79; CDK; Cyclin Dependent Kinase; CLK; CDC-Like Kinase; DCM; dichloromethane; DDQ; 2,3-Dichloro-5,6-DicyanobenzoQuinone; DIPEA; N,N-diisopropylethylamine; DLBCL;
Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes
Keywords: جایگزینی معطر Nucleophilic; ADME; absorption, distribution, metabolism and excretion; Clint; intrinsic clearance; Clp; plasma clearance; Clu; unbound clearance; DCM; dichloromethane; DHEP; dog hepatocytes; DLM; dog liver microsomes; DMAc; dimethylacetamide; DMF; dimethylformamide; D
Convenient two-step synthesis of highly functionalized benzo-fused 1,4-diazepin-3-ones and 1,5-diazocin-4-ones by sequential Ugi and intramolecular SNAr reactions
Keywords: جایگزینی معطر Nucleophilic; Fused heterocycles; Multicomponent reaction; Ugi reaction; Nucleophilic aromatic substitution; Benzodiazepinones;
Brevetoxin-2, is a unique inhibitor of the C-terminal redox center of mammalian thioredoxin reductase-1
Keywords: جایگزینی معطر Nucleophilic; Karenia brevis; Brevetoxin; Thioredoxin; Thioredoxin reductase; BSA; bovine serum albumin; DTNB; Ellman's reagent: 5,5â²-dithio-bis-(2-nitrobenzoic acid); ESI; electrospray ionization; FAD; flavin adenine dinucleotide; FT-ICR; Fourier transform ion cyclo
Substitution chemistry of 3,5-dichloro-4H-1,2,6-thiadiazine 4,4-ketals
Keywords: جایگزینی معطر Nucleophilic; Heterocyclic chemistry; C-C coupling; Protecting groups; Nucleophilic aromatic substitution;
Facile entry into structurally diverse, privileged, (hetero)arene-fused N-alkoxy 3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-ones
Keywords: جایگزینی معطر Nucleophilic; Tandem cyclization; Nucleophilic aromatic substitution; Smiles rearrangement; Tricyclic scaffolds; Benzo[1,4]oxazepines; Privileged structures; Lossen rearrangement;
Development of N6-methyl-2-(1,2,3-triazol-1-yl)-2â²-deoxyadenosine as a novel fluorophore and its application in nucleotide synthesis
Keywords: جایگزینی معطر Nucleophilic; Triazolyl purine derivatives; Nucleophilic aromatic substitution; Azide reduction; Fluorescence; Oligonucleotides;
Atom-economical construction of tetracyclic [1,4]oxazepines involving intramolecular arylation of a 2-imidazoline moiety
Keywords: جایگزینی معطر Nucleophilic; Imidazoline arylation; Monoamine uptake inhibitors; Polycyclic aromatic scaffolds; Smiles rearrangement; Nucleophilic aromatic substitution; Regiospecificity;
Poly(arylene ether)s derived from N-alkyl-N-phenyl-3,5-difluorobenzene sulfonamides: Effect of alkyl chain length on the glass transition temperature
Keywords: جایگزینی معطر Nucleophilic; Poly(arylene ether)s; Nucleophilic aromatic substitution; Meta-activation; Thermal properties; Glass transition temperature; Structure–property relationships
A novel route to 4,4â²-disubstituted bipyridyl ligands in ruthenium complexes for dye-sensitized solar cells
Keywords: جایگزینی معطر Nucleophilic; Ruthenium(II) complex; Dye-sensitized solar cells; Nucleophilic aromatic substitution; Bipyridyl; Impedance;
The gas-phase reactions of localized and delocalized carbanions with aryl halides: Competition between attack on the π-system and the periphery
Keywords: جایگزینی معطر Nucleophilic; Nucleophilic aromatic substitution; SN2; Ion–molecule reaction; Ion trap mass spectrometry
A complementary route to diaminopyrimidines through regioselective SNAr amination reactions
Keywords: جایگزینی معطر Nucleophilic; Diaminopyrimidines; Nucleophilic aromatic substitution; Regioselectivity; Tetrafluorophenoxy;
Efficient one-pot synthesis of 3,7-disubstituted 1,6-naphthyridin-2(1H)-ones through regioselective palladium-catalyzed cross-coupling and SNAr reactions
Keywords: جایگزینی معطر Nucleophilic; Nitrogen-containing heterocycles; C-N bond formation; Buchwald-Hartwig coupling; Suzuki-Miyaura cross-coupling; Nucleophilic aromatic substitution;
Aryl methyl sulfides via SNAr using DMSO as the source of the thiomethyl moiety
Keywords: جایگزینی معطر Nucleophilic; Dimethylsulfoxide; Nucleophilic aromatic substitution; Methyl sulfides; Thiomethyl; Hunig's base;
Pyrido[3,2-b][1,4]oxazine and pyrido[2,3-b][1,4]benzoxazine systems from tetrafluoropyridine derivatives
Keywords: جایگزینی معطر Nucleophilic; Organofluorine chemistry; Perfluoroaromatic; Nucleophilic aromatic substitution; Tetrafluoropyridine; Pyrido[3,2-b][1,4]oxazine; Pyrido[2,3-b][1,4]benzoxazine;
Simple and catalyst-free method for the synthesis of diaryl selenides by reactions of arylselenols and arenediazonium salts
Keywords: جایگزینی معطر Nucleophilic; Organoselenium compounds; Selenol; Arenediazonium salts; Hypophosphorous acid; Nucleophilic aromatic substitution;
A mild method for the synthesis of a novel dehydrobutyrine-containing amino acid
Keywords: جایگزینی معطر Nucleophilic; Pentafluoropyridine; Nucleophilic aromatic substitution; Dehydrobutyrine; Amino acid;
Reactions of selected 3-bromoisothiazole-5-carbonitriles with the secondary dialkylamines pyrrolidine and morpholine
Keywords: جایگزینی معطر Nucleophilic; Heterocycles; Isothiazoles; Nucleophilic aromatic substitution; Heteroaromatic chemistry; Sulfur heterocycles;
A two-step, one-pot route to swap the pyrroline moiety in meso-tetraaryldihydroxy-chlorins with an O/N-substituted oxazoline
Keywords: جایگزینی معطر Nucleophilic; HHYKYIXSSLREHP-LNUQCFDESA-N; IETGEQYFSBZKFR-VPUFTUDCSA-N; RTBLGEDFXJTOBL-RTDJMSDGSA-N; Porphyrins; Porphyrinoids; Chlorins; Chlorin analogues; Nucleophilic aromatic substitution;
1,2,3-Triazoles as leaving groups in purine chemistry: a three-step synthesis of N6-substituted-2-triazolyl-adenine nucleosides and photophysical properties thereof
Keywords: جایگزینی معطر Nucleophilic; Triazolyl purine derivatives; Nucleophilic aromatic substitution; Click chemistry; Fluorescence; Nucleoside analogs;
Utilization of N,N-diethyl-3,5-difluorobenzene sulfonamide to prepare functionalized poly(arylene ether)s
Keywords: جایگزینی معطر Nucleophilic; Poly(arylene ether)s; Nucleophilic aromatic substitution; Meta activation;
19F and 13C GIAO-NMR chemical shifts for the identification of perfluoro-quinoline and -isoquinoline derivatives
Keywords: جایگزینی معطر Nucleophilic; Perfluoroheteroaromatic; Nucleophilic aromatic substitution; Perfluoroquinoline; NMR spectroscopy;
Synthesis and evaluation of heteroaryl substituted diazaspirocycles as scaffolds to probe the ATP-binding site of protein kinases
Keywords: جایگزینی معطر Nucleophilic; AGC; protein kinases A G and C; ATP; adenosine triphosphate; 9-BBN; 9-borabicyclo[3.1.1.]nonane Boc tert-butyloxycarbonyl; CAMK; calcium/calmodulin-dependent kinases; Cbz; benzyloxycarbonyl; DFG; aspartate-phenylalanine-glycine sequence; DIBAL-H; diis
Efficient synthesis of unsymmetrical diaryl thioethers via TBAF-mediated denitrative substitution of nitroarenes with PhSTMS under mild and neutral conditions
Keywords: جایگزینی معطر Nucleophilic; Phenylthiotrimethylsilane; Nitroarenes; Denitrative substitution; Unsymmetrical diaryl thioethers; Nucleophilic aromatic substitution
Highly selective and sensitive fluorescent sensing of N-acetylcysteine: Effective discrimination of N-acetylcysteine from cysteine
Keywords: جایگزینی معطر Nucleophilic; N-Acetylcysteine; Fluorescent probe; 2,4-dinitrophenyl ether; N,N-Diethylrhodol; Cetyltrimethylammonium bromide; Nucleophilic aromatic substitution
A three-step synthesis of 4-(4-iodo-1H-pyrazol-1-yl)piperidine, a key intermediate in the synthesis of Crizotinib
Keywords: جایگزینی معطر Nucleophilic; Iodination; Hydrogenation; Nucleophilic aromatic substitution; Palladium; Piperidine;
Synthesis and molecular structure of a perfluorinated pyridyl carbanion
Keywords: جایگزینی معطر Nucleophilic; Perfluoroaromatic; Perfluoroheterocyclic; Pentafluoropyridine; Perfluorocarbanion; Nucleophilic aromatic substitution
Reaction of nitroalkanes with polyfluoroaromatic compounds
Keywords: جایگزینی معطر Nucleophilic; Nucleophilic aromatic substitution; Pentafluorobenzonitrile; Methyl pentafluorobenzoate; Reduction with tri-n-butyltin hydride; Nef reaction with TiCl3; Michael reaction
Convenient synthesis of α-perfluoroaryl and α-perfluorohetaryl substituted α-aminomethanephosphonates
Keywords: جایگزینی معطر Nucleophilic; α-Aminophosphonates; Fluorinated compounds; Nucleophilic aromatic substitution; Carbanions
A highly selective wavelength-ratiometric and colorimetric probe for cysteine
Keywords: جایگزینی معطر Nucleophilic; Ratiometric; Colorimetric; Cysteine; Probe; Nucleophilic aromatic substitution; Naphthalimide
Reactions of 4-substituted tetrafluoropyridine derivatives with sulfur nucleophiles: SNAr and annelation processes
Keywords: جایگزینی معطر Nucleophilic; Perfluoroaromatic; Perfluoroheterocyclic; Nucleophilic aromatic substitution; Tetrafluoropyridine; Thieno[2,3-c]pyridine
Synthesis of aryl azides: A probe reaction to study the synergetic action of ultrasounds and ionic liquids
Keywords: جایگزینی معطر Nucleophilic; Ionic liquids; Ultrasounds; Aryl azides; Nucleophilic aromatic substitution
Route selection in the synthesis of C-4 and C-6 substituted thienopyrimidines
Keywords: جایگزینی معطر Nucleophilic; Thienopyrimidine; Suzuki coupling; Nucleophilic aromatic substitution; Gewald synthesis; Arylboronic acid;
Study on the synthesis of 6-alkylaminouridines via the nucleophilic aromatic substitution reaction of 6-cyanouridine derivatives
Keywords: جایگزینی معطر Nucleophilic; 6-Cyanouracil; 6-Cyanouridine; 6-Alkylaminouracil; 6-Alkylaminouridine; Nucleophilic aromatic substitution;
Polyfluorinated cycloalkoxyphenyl ether systems as dopants for liquid crystal display applications
Keywords: جایگزینی معطر Nucleophilic; Liquid crystal; Perfluoroaromatic; Nucleophilic aromatic substitution
Synthesis of novel 1,2,5-trisubstituted benzimidazoles as potential antitumor agents
Keywords: جایگزینی معطر Nucleophilic; Nucleophilic aromatic substitution; Pyrazole derivatives; Trisubstituted benzimidazoles; Solvent free reaction conditions; Antitumor agents
Synthesis of tetrahydropyrido- and pyrido-[1â²,2â²:1,2]imidazo[4,5-b]pyrazine derivatives
Keywords: جایگزینی معطر Nucleophilic; Heterocycle; Pyridazine; Perfluoroheteroaromatic; Scaffold; Nucleophilic aromatic substitution;
Microwave-assisted synthesis of 4-amino-3,5-dihalopyridines
Keywords: جایگزینی معطر Nucleophilic; Amines; Coupling; Nucleophilic aromatic substitution; Pyridines; Microwave-assisted synthesis;
Unprecedented N(H)-bridged tetraaza[1.1.1.1]m,p,m,p-cyclophanes
Keywords: جایگزینی معطر Nucleophilic; Macrocycle; Cyclophane; Nucleophilic aromatic substitution;