l-Proline catalyzed condensation–cyclization tandem process: Facile and effective synthesis of 3-polyfluoroalkanesulfonyl coumarin

A l-proline catalyzed condensation–cyclization tandem process is reported, which affords the potentially pharmaceutic coumarin derivatives. The mild conditions, simplicity of the purification process and satisfactory yields makes the method a facile and effective way toward the 3-polyfluoroalkanesulfonyl coumarins.

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► A l-proline catalyzed condensation–cyclization tandem process is reported.
► The reaction gave the potentially pharmaceutic coumarin derivatives in good yields.
► The mild condition, simplicity of the purification process and satisfactory yields makes the method a facile and effective way toward the 3-polyfluoroalkanesulfonyl coumarins.
► And a possible reaction pathway was proposed.