Synthesis and biological evaluation of γ-fluoro-β,γ-unsaturated acids

Several γ-fluoro-β,γ-unsaturated acids, fluorine-containing analogues of N-acyl glycines, were synthesized via Julia-Lythgoe olefination. The antimicrobial activities of these compounds and synthetic intermediates were evaluated. Analogues with an octyl group showed in vitro antifungal activity against Penicillium chrysogenum IFO4626.