کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1334390 | 1500245 | 2015 | 8 صفحه PDF | دانلود رایگان |
An 8-aminoquinoline based fluorescent Zn2+ sensor, 2-methoxy-6-((quinolin-8-ylimino)methyl)phenol (HL), was synthesized. It has been found to display quick responses through fluorogenic properties on selective 2:1 binding to Zn2+, as delineated by absorption and fluorescence titrations as well as by Job’s method and X-ray crystallography studies. This probe features visible light excitation (461 nm) and emission (594 nm) profiles, excellent selectivity responses for Zn2+ over other competing biological metal ions with high binding constant and about 17-fold enhancement in fluorescence quantum yield (Φ) upon half equivalent of Zn2+ binding under physiological pH window. The low detection limit in micromolar range (1.3 × 10−7 M) for Zn2+, makes HL a suitable candidate for the development of a potential probe. It also exhibits cell permeability and intracellular Zn2+ sensing in HeLa cells from human cervical cancer cell and rat hippocampal slices.
An 8-aminoquinoline based fluorescent Zn2+ sensor, 2-methoxy-6-((quinolin-8-ylimino)methyl)phenol (HL), was synthesized. It has been found to display quick responses through fluorogenic properties on selective 2:1 binding to Zn2+, as delineated by absorption and fluorescence titrations as well as by Job’s method and X-ray crystallography studies. This probe features visible light excitation (461 nm) and emission (594 nm) profiles, excellent selectivity responses for Zn2+ over other competing biological metal ions with high binding constant and about 17-fold enhancement in fluorescence quantum yield (Φ) upon half equivalent of Zn2+ binding under physiological pH window. The low detection limit in micromolar range (1.3 × 10−7 M) for Zn2+, makes HL a suitable candidate for the development of a potential probe. It also exhibits cell permeability and intracellular Zn2+ sensing in HeLa cells from human cervical cancer cell and rat hippocampal slices.Figure optionsDownload as PowerPoint slide
Journal: Polyhedron - Volume 94, 7 July 2015, Pages 75–82