کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1334431 1500258 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Conformational polymorphism of a zinc complex with enalapril antihypertensive drug
ترجمه فارسی عنوان
پلیمورفیسم سازگاری یک ترکیب روی با داروهای ضد فشار خون انالاپریل
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
چکیده انگلیسی

The crystal structure of an enalapril-Zn complex was determined by X-ray diffraction at various temperatures. The complex consisted of the drug enalapril coordinated to a Zn2+ ion by the oxygen atom of the carboxylate group in the monodentate mode. The metal ion produced a tetrahedral geometry, indicating that the enalapril complexation with a Zn2+ ion in vitro is similar to that suggested in vivo. The crystal structure of the enalapril-Zn complex showed an irreversible order–disorder structural phase transition in the temperature range of 150–200 K during the cooling process. A symmetry change from C222 at room temperature (Phase I) to P212121 at 150 K (Phase II) was observed. Phase I presented pronounced occupational disorder, whereas Phase II was slightly disordered.

The crystal structure of an enalapril-Zn complex was determined by X-ray diffraction. Enalapril-Zn showed an irreversible order-disorder structural phase transition. Symmetry changes from C222 at room temperature to P212121 at 150 K were observed. Phases I and II presented the polymorphism phenomenon.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polyhedron - Volume 81, 15 October 2014, Pages 290–297
نویسندگان
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