کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1334965 979487 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increasing the antibacterial activity of gallium(III) against Pseudomonas aeruginosa upon coordination to pyridine-derived thiosemicarbazones
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Increasing the antibacterial activity of gallium(III) against Pseudomonas aeruginosa upon coordination to pyridine-derived thiosemicarbazones
چکیده انگلیسی

Reaction of N(4)-phenyl-2-formylpyridine thiosemicarbazone (H2Fo4Ph), N(4)-phenyl-2-acetylpyridine thiosemicarbazone (H2Ac4Ph) and N(4)-phenyl-2-benzoylpyridine thiosemicarbazone (H2Bz4Ph) with gallium nitrate gave [Ga(H2Fo4Ph)2](NO3)3 (1), [Ga(2Ac4Ph)2]NO3 (2) and [Ga(2Bz4Ph)2]NO3 (3). In all complexes coordination of the thiosemicarbazone via the Npy–N–S chelating system occurs. In 1 the thiosemicarbazone acts as a neutral ligand while in 2 and 3 the ligand is anionic. Upon slow diffusion of 2 in DMSO [Ga(2Ac4Ph)2]NO3·DMSO (2a) was formed. The crystal structure of 2a was determined. Upon coordination the antibacterial activity of both gallium and thiosemicarbazones against Pseudomonas aeruginosa significantly increases.

Reaction of N(4)-phenyl-2-formylpyridine thiosemicarbazone (H2Fo4Ph, HL1), N(4)-phenyl-2-acetylpyridine thiosemicarbazone (H2Ac4Ph, HL2) and N(4)-phenyl-2-benzoylpyridine thiosemicarbazone (H2Bz4Ph, HL3) with gallium nitrate gave [Ga(H2Fo4Ph)2](NO3)3 (1), [Ga(2Ac4Ph)2]NO3 (2) and [Ga(2Bz4Ph)2]NO3 (3). In all complexes coordination of the thiosemicarbazone via the Npy–N–S chelating system occurs. Upon coordination the antibacterial activity of both gallium and thiosemicarbazones against Pseudomonas aeruginosa significantly increases.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polyhedron - Volume 28, Issue 11, 6 July 2009, Pages 2301–2305
نویسندگان
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