کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1335215 1500242 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, structures and insulin-like activity of oxidovanadium(V) complexes with aroylhydrazones and ethylmaltol mixed-ligands
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Synthesis, structures and insulin-like activity of oxidovanadium(V) complexes with aroylhydrazones and ethylmaltol mixed-ligands
چکیده انگلیسی

Three new oxidovanadium(V) complexes with formula [VOLL′] (L = L1 = N′-(2-hydroxy-4-methoxybenzylidene)-4-hydroxybenzohydrazide for 1, L = L2 = N′-(3-ethoxy-2-hydroxybenzylidene)pivalohydrazide for 2, L = L3 = 2-bromo-N′-(3-ethoxy-2-hydroxybenzylidene)benzohydrazide for 3, L′ = ethylmaltol), have been prepared. The complexes have been characterized by physico-chemical methods and single crystal X-ray determination. The V atom in each complex is coordinated by the NOO donor atoms of L, the OO donor atoms of L′, and one oxido group, forming octahedral coordination. The complexes were administered intragastrically to both normal and alloxan-diabetic mices for two weeks. The biological activity results show that the complexes at doses of 10.0 and 20.0 mg V·kg−1, can significantly decrease the blood glucose level in alloxan-diabetic mices, but the blood glucose level in the treated normal mices was not altered.

Three new oxidovanadium(V) complexes with aroylhydrazones and ethylmaltol mixed ligands were prepared and structurally characterized. The complexes can significantly decrease the blood glucose level in alloxan-diabetic mices.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polyhedron - Volume 97, 5 September 2015, Pages 268–272
نویسندگان
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