Synthesis, structure, physico-chemical and biological properties of metal(II) complexes with 5-amino-8-methyl-4H-benzopyran-4-one

Two new complexes of a previously obtained chromone derivative, 5-amino-8-methyl-4H-benzopyran-4-one (ligand 1), with the Co(II) (4) and Pd(II) (5) ions were synthesized and characterized by elemental analysis, IR and mass spectroscopy. The previously characterized Cu(II) complexes (2 and 3) and the newly obtained complexes of ligand 1 with Pd(II) and Co(II) have been tested as potential anticancer compounds. The molecular structure of 5 has been determined by X-ray crystallography. Biological properties, such as cytotoxicity against several cancer cell lines, the influence of the obtained compounds on the DNA structure by CD spectroscopy and agarose gel electrophoresis, have been evaluated. Also some physico-chemical properties, such as lipophilicity and stability in the aqueous solution, were tested.

The 5-amino-8-methyl-4H-benzopyran-4-one ligand (1) has been used to obtain a new complexes with Co(II) (4) and Pd(II) (5) as well as previously characterized Cu(II) complexes (2 and 3). Both newly obtained compounds were characterized by IR and mass spectrometry. The molecular structure of 5 has been determined by X-ray crystallography. Biological abilities, such as cytotoxicity against cancer cells and the influence of the obtained compounds on the DNA structure, have been evaluated. Also some physico-chemical properties, such as lipophylicity and stability in the aqueous solution, were tested.Figure optionsDownload as PowerPoint slide