کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1335554 | 1500276 | 2013 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Structural and functional comparison of manganese-, iron-, cobalt-, nickel-, and copper-containing biomimic quercetinase models Structural and functional comparison of manganese-, iron-, cobalt-, nickel-, and copper-containing biomimic quercetinase models](/preview/png/1335554.png)
A series of divalent transition metal (Mn, Fe, Co, Ni, and Cu) flavonolate (Fla) complexes MII(Fla)(L1), and MII(Fla)(L2)X (X = Cl or ClO4) with the ligands N-propanoate-N,N-bis(2-pyridylmethyl)amine (L1 = HPBMPA) and N-methylpropanoate-N,N-bis(2-pyridylmethyl)amine (L2 = MPBMPA) have been prepared and characterized by spectroscopic methods and two cases by X-ray crystal analysis. The coordination sphere of the central ions is distorted octahedral with N3 or N3O donor sets, which are good structural models for the cupin-type metal-containing flavonol 2,4-dioxygenases (FDO). The dioxygenation of the metal flavonolate complexes results in the oxidative cleavage of the heterocyclic ring to give the corresponding O-benzoylsalicylate complexes and carbon monoxide as biomimic FDO models. The bathochromic shift of the absorption band I (π–π∗) of the coordinated flavonolate is influenced by the metals, and a linear correlation was observed between the logarithm of the reaction rate constant with O2 and the degree of the bathochromic shift (Δλ), providing a mechanistic insight into the stoichiometric dioxygenation reactions.
This study reports the preparation and characterization of a series of divalent transition metal (Mn, Fe, Co, Ni, and Cu) flavonolate (Fla) complexes MII(Fla)(L1), and MII(Fla)(L2)X (X = Cl or ClO4) with N3 or N3O donor sets, which are good structural and functional models for the cupin-type metal-containing flavonol 2,4-dioxygenases (FDO).Figure optionsDownload as PowerPoint slide
Journal: Polyhedron - Volume 63, 31 October 2013, Pages 41–49