کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1335615 | 1500230 | 2016 | 7 صفحه PDF | دانلود رایگان |
Metal dyshomeostasis and oxidative stress have been linked to numerous diseases such as Alzheimer’s and Parkinson’s diseases, cancer and so forth. Herein, we report the synthesis, chelating and antioxidant ability of two novel derivatives of biotin endowed with an 8-hydroxyquinoline moiety.This family of chelators under study is potentially relevant in the treatment of diseases related to metal dyshomeostasis.The biotin-8-hydroxyquinoline conjugates and their metal complexes with manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) were characterized by several techniques such as NMR, ESI-MS and UV–Vis. Moreover, the capacity of these ligands and complexes to act as antioxidants was evaluated. The collected information may provide new insights and suggest further strategies for the development of 8-hydroxyquinoline derivatives for the control of metal dyshomeostasis and oxidative stress.
Two novel derivatives of biotin endowed with an 8-hydroxyquinoline moiety were synthetized and characterized. Their metal complexes were studied in solution and evaluated as antioxidant agents.Figure optionsDownload as PowerPoint slide
Journal: Polyhedron - Volume 110, 28 May 2016, Pages 254–260