A copper(II) complex with pyridine-2,6-dicarboxylic acid: Synthesis, characterization, thermal decomposition, bioactivity and interactions with herring sperm DNA

The copper(II) complex of pyridine-2,6-dicarboxylic acid was synthesized and characterized by elemental analyses, single crystal X-ray diffraction, FTIR and UV–Vis spectra, and thermogravimetric analysis coupled with infrared spectrometry (TGA-FTIR). The results show that the crystal structure of the complex belongs to the triclinic system, and the Cu(II) ion is five-coordinated by one pyridine N atom, two carboxylate O atoms from the ligand anion and two O atoms from two water molecules, forming a distorted triangular bipyramidal geometry. Under the conditions of a physiological pH environment, the interaction of the complex with herring sperm DNA was studied by means of spectral methods using acridine orange as a fluorescence probe. The bonding mode between the complex and DNA is evidenced to be intercalative binding, and the binding of the complex to DNA is driven by entropy.

The copper(II) complex of pyridine-2,6-dicarboxylic acid was synthesized and characterized by elemental analyses, single crystal X-ray diffraction, FTIR and TGA-FTIR. The interactions of the complex with herring sperm DNA was studied by means of spectral methods using acridine orange as a fluorescence probe.Figure optionsDownload as PowerPoint slide