کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1336158 | 979572 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Multi-biofunctional complexes combining antiseptic copper(II) with antibiotic sulfonamide ligands: Structural, redox and antibacterial study Multi-biofunctional complexes combining antiseptic copper(II) with antibiotic sulfonamide ligands: Structural, redox and antibacterial study](/preview/png/1336158.png)
Copper(II) and nickel(II) complexes of sulfadimethoxine, sulfadiazine, sulfamerazine and sulfamethazine were synthesized with a good yield according to an original procedure. These complexes were first characterized by single-crystal X-ray diffraction and electrochemistry. Structural inspections showed that the antibacterial entity of ligands remains non-coordinated to metal ions in the complex high-lighting the fact that in each cluster, antiseptic activity of the metal has been associated to the antibiotic activity of the ligand. In order to confirm this possibility, antibacterial activities of the complexes were studied on several bacteria. The antibacterial activity of the complex is as important as the ligands one with the addition of antiseptic activity via the incorporation of copper ions.
Elaboration of five new hybrid inorganic–organic complexes associating antibacterial and antiseptic properties via an original synthetic route. Their activities have been tested with Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniaFigure optionsDownload as PowerPoint slideHighlights
► Easy synthesis reaction of Sulfonamide- based complexes.
► X-ray diffraction characterization.
► Electrochemical studies of antibiotic ligands and complexes.
► Antibacterial activity studies.
Journal: Polyhedron - Volume 30, Issue 10, 14 June 2011, Pages 1663–1670