کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1337278 979625 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Urease inhibitory activities of ZnBr2 and ZnI2 complexes of terpyridine derivatives: Systematic investigation of aryl substituents on urease inhibitory activities
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Urease inhibitory activities of ZnBr2 and ZnI2 complexes of terpyridine derivatives: Systematic investigation of aryl substituents on urease inhibitory activities
چکیده انگلیسی

With the aim of discovering novel urease inhibitors, six new mononuclear complexes of five-coordinated Zn(II) bromide and iodide with terpyridine derivatives have been synthesized and their solid state structures were characterized by X-ray crystallography. Among these complexes, the zinc complexes bearing an electron withdrawing aryl group at the 4′-position show medium urease inhibitory activities, with IC50 values much lower than those of previously reported zinc species, at concentrations lower than 100 mM.

To explore novel urease inhibitors, six new complexes of Zn(II) with terpyridine derivatives have been prepared and structurally characterized. Among these complexes, electron withdrawing substituted complexes show stronger urease inhibition.Figure optionsDownload as PowerPoint slideHighlights
► 4′-Substituted terpyridine derivatives were synthesized by simple procedures.
► Zinc bromide and zinc iodide complexes of the ligands were prepared and carefully characterized.
► Urease inhibitory activity of the free ligands as well as the zinc complexes was evaluated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polyhedron - Volume 45, Issue 1, 19 September 2012, Pages 9–14
نویسندگان
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