کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1338173 | 979661 | 2012 | 9 صفحه PDF | دانلود رایگان |
The chromone derivative 5-amino-8-methyl-4H-benzopyran-4-one (ligand) (1) has been used to obtain a series of Cu(II) complexes 2–4 as potential anticancer compounds. The molecular structures of ligand 1 and its Cu(II) complex 3 have been determined by X-ray crystallography. The cytotoxicity of all obtained compounds has been evaluated on melanoma A375 cell line. The ability of compounds 1–4 to take part in redox reactions and their antioxidant activity have been studied.
Three new Cu(II) complexes containing the ligands 5-amino-8-methyl-4H-chromen-4-one (1) with different anions were prepared and fully characterized, especially ligand 1 and complex 3 by X-ray diffraction analyses. Ligand 1 exerts moderate antioxidant but not anticancer activity, and complexes did not show enhanced antioxidant activity but increased cytotoxic activity.Figure optionsDownload as PowerPoint slide
Journal: Polyhedron - Volume 31, Issue 1, 4 January 2012, Pages 150–158