Functionalized bipyridyl rhodium complex capable of electrode attachment for regeneration of NADH

A Rh(III) complex having a functionalized bpy-OH ligand that is potentially linkable to electrode surfaces was synthesized and fully characterized. The hydrido complex, which could be generated either electrochemically by cathodic reduction of the [η5-Cp∗Rh(bpy-OH)Cl]Cl complex at −771 mV (versus Ag/AgCl) or chemically with formate, transformed NAD+ efficiently into NADH with a TOF = 710 at 60 °C.

A rhodium complex with free hydroxyl groups was synthesized and well characterized by single crystal X-ray analysis. Indirect electrochemical and chemical methods of regeneration of NADH are presented.Figure optionsDownload as PowerPoint slide