New phosphoroamidate compounds: Synthesis, structural characterization and studies on ZnCl2 assisted hydrolysis of the P–N bond

A variety of phosphorodiamidate compounds were synthesized from the corresponding phosphorodichloridate intermediates and phosphorus oxychloride. These were completely characterized using different spectroscopic methods and single crystal X-ray diffraction studies on one of them. Studies revealed that water in the presence of a mild Lewis acid like ZnCl2 was found to assist the hydrolysis of the P–N linkage. The proof of this concept was effectively realized through the hydrolysis of hexamethylphosphoramide.

Hydrolysis of the P–N bond using a mild Lewis acid like ZnCl2 for new phosphorodiamidate compounds and hexamethylphosphoramide is described.Figure optionsDownload as PowerPoint slide