Synthesis and biological activity of triorganogermanium substituted heteropolytungstates

Four new compounds, [Me4N]4H5[(RGe)3(XW9O34−n)2] (R = HOOCCH2CH2, HOOCCH2(m-NO2C6H4)CH, X = P, n = 0; X = Sb, n = 1) have been prepared from trichlorogermanium precursors and lacunary polyoxometallates ([PW9O34]9− and [SbW9O33]9−). The products were characterized by means of elemental analysis, IR spectroscopy, 1H NMR and 183W NMR spectroscopy. 183W NMR spectra of the complexes support the stoichiometry of the new heteropolyanions and the probable retention of the XW9 units in water. The organogermanium substituted complexes showed promising activity against two human tumor cell lines (leucocythemia Hela cells and S180 cells) in vitro and [Me4N]4H5[(HOOCCH2CH2Ge)3(SbW9O33)2] exhibited some certain antitumoral activity in vivo and can increase the immune ability of the spleen.

Four new compounds, [Me4N]4H5[(RGe)3(XW9O34−n)2] (R = HOOCCH2CH2, HOOCCH2(m-NO2C6H4)CH, X = P, n = 0; X = Sb, n = 1) have been prepared from trichlorogermanium precursors and lacunary polyoxometallates ([PW9O34]9− and [SbW9O33]9−). The products were characterized by means of elemental analysis, IR spectroscopy, 1H NMR and 183W NMR spectroscopy. 183W NMR spectra of the complexes support the stoichiometry of the new heteropolyanions and the probable retention of the XW9 units in water. The organogermanium substituted complexes showed promising activity against two human tumor cell lines (leucocythemia Hela cells and S180 cells) in vitro and [Me4N]4H5[(HOOCCH2CH2Ge)3(SbW9O33)2] exhibited some certain antitumoral activity in vivo and can increase the immune ability of the spleen.Figure optionsDownload as PowerPoint slide