Synthesis, characterization, crystal structure and antiproliferative activity of platinum(II) complexes with 2-acetylpyridine-4-cyclohexyl-thiosemicarbazone

New platinum complexes have been synthesized by the reaction of Na2PtCl4 with 2-acetylpyridine-4-cyclohexyl-thiosemicarbazone, HAc4CyclHexyl (1). The new complexes [Pt(Ac4CyclHexyl)Cl] (2) and [Pt(Ac4CyclHexyl)2] (3) have been characterized by elemental analyses, spectroscopic studies and the crystal structure of the complex [Pt(Ac4CyclHexyl)Cl] · DMF has been solved by single-crystal X-ray diffraction. The results of the cytotoxic activity of 1-3 have been evaluated for antiproliferative activity in vitro against the cells of three human cancer cell lines: MCF-7, T24 (bladder cancer cell line), A-549 and a mouse L-929. The compounds 1-3 display IC50 values in a μM range better than that of the antitumor drug cisplatin and are considered as agents with potential antitumor activity candidates for further stages of screening in vitro and/or in vivo.