Alkaloid chemotypes of Glaucium flavum (Papaveraceae) from Bulgaria

• Nine alkaloids were identified in Glaucium flavum Crantz. from four natural populations in Bulgaria.
• The alkaloid profiles of G. flavum from four natural populations were compared.
• On the basis of alkaloid profiles has been found three alkaloid chemotype of G. flavum from Bulgaria.

The alkaloid pattern of Glaucium flavum Crantz. from four natural populations in Bulgaria were investigated and six aporphine, two protopine and one morphinane alkaloids were determined. In accordance with the particular content and composition of alkaloids and the different localities of the species three alkaloid chemotypes were suggested. The first one contains aporphines and protopines with a main alkaloid glaucine. The second chemotype contains again aporphine and protopine alkaloids but the main alkaloid is isocorydine and the third chemotype contains besides these two types of alkaloids and the morphinane alkaloid salutaridine.