|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|1368488||981701||2016||4 صفحه PDF||سفارش دهید||دانلود رایگان|
A new bergenin derivative, bergenin-11-O-α-d-galactopyranoside (compound 1), together with seven known polyphenolic compounds, were isolated from the stem of Cissus pteroclada Hayata. The structures of the 8 compounds were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Moreover, the in vitro anti-inflammatory effects of compounds (1–8) in LPS-stimulated murine macrophage RAW 264.7 cells were also investigated. Our results revealed that compound 1 inhibited the production of pro-inflammatory mediators NO and PGE2 and the expression of NF-κB, TNF-α, IL-1β, iNOS and COX-2.
The structure of new bergenin derivative, bergenin-11-O-α-d-galactopyranoside (1) isolated from the stem of Cissus pteroclada Hayata has been determined by detailed spectroscopic analyses. The in vitro anti-inflammatory activity assay of the compounds 1–8 indicated that bergenin derivatives (1–4) exhibited significant anti-inflammatory effects via modulation of NF-κB activation.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 15, 1 August 2016, Pages 3425–3428