کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1392076 1501116 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
11-Keto-boswellic acid derived amides and monodesmosidic saponins induce apoptosis in breast and cervical cancers cells
ترجمه فارسی عنوان
آمید های مشتق شده از اسید 11-کتو-بوسولیک و سابونین های مونوادوزیدیک باعث ایجاد آپوپتوز در سلول های سرطانی سینه و گردن می شوند
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی


• A variety of 11-keto-β-boswellic acid derivatives was investigated.
• The compounds showed antitumor activity on different human cancer cell lines.
• Many of the compounds are cytotoxic even in a low micro mol concentration.
• An amide at position C-24 increases cytotoxicity.
• Monodesmosidic saponins showed an increased cytotoxicity.

Beta-boswellic acids are considered the main bioactive components of frankincense. Their potential to act as cytotoxic agents, as well as that of their derivatives remained unexploited so far. In this study we were able to prepare derivatives of 11-keto-β-boswellic acid (KBA) that showed lower IC50 values as determined by a sulphorhodamine B (SRB) assay using several different human tumour cell lines. Monodesmosidic saponins of KBA are as cytotoxic as 3-acetyl-KBA. The presence of a free hydroxyl group at position C-3 seems to lower cytotoxicity while the presence of an amide function at C-24 improves cytotoxicity. The most active compound of this series gave IC50 values as low as 4.5 μM. Cell death proceeded mainly via apoptosis.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 100, 15 July 2015, Pages 98–105
نویسندگان
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