کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1392305 1501131 2014 32 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A comprehensive review on synthetic approach for antimalarial agents
ترجمه فارسی عنوان
بررسی جامع در مورد روش مصنوعی برای عوامل ضد مالاریا
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی


• Different classes of active antimalarial agents.
• Heterocyclic atom based classification of potential antimalarials.
• Synthetic strategies followed for the synthesis of antiparasitic agents.
• IC50 of the most active analog of corresponding series of derivatives.

Malaria has emerged as a major health problem worldwide after the appearance of resistant strains of Plasmodium falciparum to the most of antimalarial drugs. The development of resistance by the parasite against first line as well as second line antimalarial drugs has drawn attention to develop new drugs to alleviate the disease burden. Therefore, there is a great need for new antimalarial drugs with improved attributes over older therapies. This review is primarily addressed to description of the recent advances in the synthesis of heterocyclic compound as antimalarial agents which can facilitate the development of more potent and effective antimalarial agents.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 85, 6 October 2014, Pages 147–178
نویسندگان
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