Inhibitors of switch kinase ‘spleen tyrosine kinase’ in inflammation and immune-mediated disorders: A review

• The structure and biology of Syk have been described.
• Role of Syk in immune cell signaling has been discussed.
• This review also includes data regarding small molecule Syk inhibitors.

Spleen tyrosine kinase (Syk), a member of Syk family of non-receptor protein tyrosine kinases plays a significant role in the immune cell signaling in B cells, mast cells, macrophages and neutrophils. Anomalous regulation of this kinase can lead to different allergic disorders and antibody-mediated autoimmune diseases such as rheumatoid arthritis, asthma, psoriasis and allergic rhinitis. Being involved in the growth and survive mechanism of B cells, its inhibition can be beneficial in B-cell lymphoma. Thus, Syk can be sited as a therapeutically relevant target for various allergic and autoimmune disorders. This review article describes the structure of Syk and its role in B-cell signaling. In addition to this, data regarding small molecule inhibitors of Syk has also been reviewed from different papers and patents published.

Spleen tyrosine kinase (Syk), non-receptor protein tyrosine kinase plays a significant role in the immune cell signaling, that can be sited as a therapeutically relevant target for various allergic and autoimmune disorders.Figure optionsDownload as PowerPoint slide