Keywords: طرز تیروزین کیناز; Urticaria; Biomarkers; CRP; IL-6; MPV; D-dimer; F1+2; Biologics; Omalizumab; ASCENT-I; ASCENT-II; GLACIAL; IL-1 antagonists; TNF-α inhibitors; Intravenous immunoglobulin; Rituximab; Ligelizumab; Quilizumab; ASST; Autologous serum skin test; ATA; Antithyr
مقالات ISI طرز تیروزین کیناز (ترجمه نشده)
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Keywords: طرز تیروزین کیناز; SYK; Spleen Tyrosine Kinase; Lead optimisation; Inhibitor; Skin penetration; Dermal;
Keywords: طرز تیروزین کیناز; AD; Alzheimer's disease; FTDP-17; frontotemporal dementia with parkinsonism linked to chromosome 17; GVD; granulovacuolar degeneration; GSK3β; glycogen synthase kinase-3β; NFTs; neurofibrillary tangles; pSyk; spleen tyrosine kinase phosphorylated at t
Keywords: طرز تیروزین کیناز; Ab; Abelson; CD; Crohn's disease; CML; Chronic myeloid leukemia; DAI; Disease activity index; DC; Dentritic cell; IBD; Inflammatory bowel disease; IL; Interleukin; LGL; Large granular lymphocytosis; MDA; Malondialdehyde; MPO; Myeloperoxidase; NFкβ; Nucl
Keywords: طرز تیروزین کیناز; Small-molecule inhibitors; Autoimmune arthritis; Janus kinases; P38; Spleen tyrosine kinase; Phosphodiesterase 4;
Keywords: طرز تیروزین کیناز; CARD; caspase recruitment domain; CLR; C-type lectin receptor; DC; dendritic cells; EAE; experimental autoimmune encephalitis; EAU; experimental autoimmune uveoretinitis; HEL; hen egg lysozyme; IRBP; interphotoreceptor retinal binding protein; MR; macroph
Keywords: طرز تیروزین کیناز; AC; adenylyl cyclase; AKT; protein kinase B; AMPK; AMP-activated protein kinase; AnR; androgen receptor; ARF6; ADP ribosylation factor 6; CaMK; Ca2+-calmodulin dependent kinase; CaMKK; CaMK kinase; cAMP; cyclic adenosine 3â²,5â²-monophosphate; CDK5; cyc
Keywords: طرز تیروزین کیناز; ACE; angiotensin I converting enzyme; AGT; angiotensinogen; APOE; apolipoprotein E; APP; amyloid beta (A4) precursor protein; AR; androgen receptor; CADASIL; cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy; CST
Keywords: طرز تیروزین کیناز; Abl; Abelson leukemia proto-oncogene; ADAP; adhesion and degranulation promoting adapter protein (Fyb, SLAP-130); Asc; apoptosis-associated speck-like protein containing a CARD; BCR; B-cell receptor; C3G; Crk SH3 domain-binding guanine nucleotide exchange
Keywords: طرز تیروزین کیناز; Aβ; β-amyloid protein; AD; Alzheimer's disease; AP-1; Activator protein-1; AS; Atherosclerosis; CCl4; Carbon tetrachloride; CFA; Complete Freund's Adjuvant; CIA; Type II collagen-induced arthritis; CMM; Chinese Material Medica; Con A; Concanavalin A; CO
Role of Malt1 protease activity in pathogenesis of inflammatory disorders mediated by FcγR signaling
Keywords: طرز تیروزین کیناز; BAC; bacteria artificial chromosome; BMDC; bone marrow-derived dendritic cell; CYLD; cylindromatosis; FBS; fetal bovine serum; FITC; fluorescein isothiocyanate; FcγR; Fcγ receptor; FcR; Fc receptor; GM-CSF; Granulocyte macrophage colony-stimulating fact
Spleen tyrosine kinase inhibition ameliorates airway inflammation through modulation of NLRP3 inflammosome and Th17/Treg axis
Keywords: طرز تیروزین کیناز; A. fumigatus; Inflammasome; Spleen tyrosine kinase; 3,4-Methylenedioxy-β-nitrostyrene; β-Glucan; Th17/Treg;
Pulsatilla decoction inhibits Candida albicans proliferation and adhesion in a mouse model of vulvovaginal candidiasis via the Dectin-1 signaling pathway
Keywords: طرز تیروزین کیناز; PD; Pulsatilla decoction; TCM; Traditional Chinese Medicine; VVC; Vulvovaginal candidiasis; HPLC; High performance liquid chromatography; CFU; Colony forming unit; PAS; Periodic acid schiff; H&E; Hematoxylin and eosin; SEM; Scanning electron microscopy; C
Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism
Keywords: طرز تیروزین کیناز; Oxidized phospholipids; Spleen tyrosine kinase; Macrophages; Bioenergetics; Cellular metabolism; Redox homeostasis; Inflammation; Ceramides;
Anti-inflammatory effects of luteolin: A review of in vitro, in vivo, and in silico studies
Keywords: طرز تیروزین کیناز; NF-κB; nuclear factor kappa B; AP-1; activator protein; STAT3; signal transducer and activator of transcription 3; NK cells; natural killer cells; TNF-α; tumor necrosis factor-α; NO; nitric oxide; iNOS; inducible nitric oxygen synthase; ROS; reactive o
Ca2+ signaling and Src-kinases-controlled cellular functions
Keywords: طرز تیروزین کیناز; Ca2+ channels; Cell signaling; Phosphatases; Receptors; Src-family kinases; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxyli
Spleen tyrosine kinase from Nile tilapia (Oreochromis niloticus): Molecular characterization, expression pattern upon bacterial infection and the potential role in BCR signaling and inflammatory response
Keywords: طرز تیروزین کیناز; Oreochromis niloticus; Spleen tyrosine kinase; Streptococcus agalactiae; BCR signaling; Inflammatory response;
Interaction of DJ-1 with Lyn is essential for IgE-mediated stimulation of human mast cells
Keywords: طرز تیروزین کیناز; Human mast cells; IgE receptor; Lyn activation; DJ-1; signaling; reactive oxygen species; spleen tyrosine kinase; Csk; C-terminal Src kinase; ERK; Extracellular signal-regulated kinase; HuMC; CD34+-derived human mast cell; JNK; c-Jun N-terminal kinase; LA
SYK protects cardiocytes against anoxia and hypoglycemia-induced injury in ischemic heart failure
Keywords: طرز تیروزین کیناز; IHD; ischemic heart disease; IHF; ischemic heart failure; SYK; spleen tyrosine kinase; HO-1; heme oxygenase-1; ROS; reactive oxygen species; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; A/H; anoxia/hypoglycemic; TBS; tris-buffere
Discovery of new Syk inhibitors through structure-based virtual screening
Keywords: طرز تیروزین کیناز; Spleen tyrosine kinase; Virtual screening; Indazole-3-carboxamide inhibitor;
A novel whey tetrapeptide IPAV reduces interleukin-8 production induced by TNF-α in human intestinal Caco-2 cells
Keywords: طرز تیروزین کیناز; CaSR; calcium sensing receptor; ESI; electric spray ionization; HPLC; high-performance liquid chromatography; IBD; inflammatory bowel disease; IL; interleukin; ERK; extracellular signal-regulated kinase; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; JN
JTE-852, a novel spleen tyrosine kinase inhibitor, blocks mediator secretion from mast cells with immunoglobulin E crosslinking
Keywords: طرز تیروزین کیناز; Spleen tyrosine kinase; JTE-852; Mast cell; IgE-crosslinking; Mediator; Allergy;
Imaging flow cytometry and GST pulldown assays provide new insights into channel catfish leukocyte immune-type receptor-mediated phagocytic pathways
Keywords: طرز تیروزین کیناز; Phagocytosis; Immunoregulatory receptors; Intracellular signaling; Actin polymerization machinery; Imaging flow cytometry; Innate immunity; Channel catfish; Leukocyte immune-type receptors; IpLITR; channel catfish leukocyte immune-type receptor; CYT; cyto
JTE-852, a novel spleen tyrosine kinase inhibitor, blocks immunoglobulin G-mediated cellular responses and autoimmune reactions in vivo
Keywords: طرز تیروزین کیناز; Spleen tyrosine kinase; JTE-852; IgG; Autoimmune disease; Animal model;
Loss of discoidin domain receptor 1 (DDR1) via CpG methylation during EMT in epithelial ovarian cancer
Keywords: طرز تیروزین کیناز; DDR1; discoidin domain receptor 1; DDR2; discoidin domain receptor 2; EMT; epithelial-mesenchymal transition; EOC; epithelial ovarian cancer; RT-qPCR; reverse transcription quantitative polymerase chain reaction; ELISA; enzyme-linked immunosorbent assay;
Suppression of IgE-mediated mast cell activation and mouse anaphylaxis via inhibition of Syk activation by 8-formyl-7-hydroxy-4-methylcoumarin, 4μ8C
Keywords: طرز تیروزین کیناز; 8-Formyl-7-hydroxy-4-methylcoumarin; 4μ8C; Mast cells; Allergy; Anaphylaxis; Lyn; Fyn; BMMC; Bone marrow-derived mast cell; RBL; Rat basophilic leukemia; PCA; Passive cutaneous anaphylaxis; ITAM; Immunoreceptor tyrosine-based activation motif; DNP-BSA; D
Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors
Keywords: طرز تیروزین کیناز; Spleen tyrosine kinase; Furano[3,2-d]pyrimidine; Syk; Rheumatoid arthritis; Kinase inhibitor;
E3 ubiquitin ligase CHIP interacts with C-type lectin-like receptor CLEC-2 and promotes its ubiquitin-proteasome degradation
Keywords: طرز تیروزین کیناز; CLEC-2; C-type lectin-like receptor 2; CHIP; C terminus of Hsc70-interacting protein; PMA; phorbol myristate acetate; CHX; cycloheximide; HEK293T; human emborynic kidney 293T; MS; mass spectrometry; FACS; fluorescence-activated cell sorting; ITAM; immunor
Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors
Keywords: طرز تیروزین کیناز; SYK; Spleen Tyrosine Kinase; Selective; Potent; Orally bioavailable; Azanaphthyridine; Lead optimisation; Medicinal chemistry;
Cholesterol crystals activate Syk and PI3 kinase in human macrophages and dendritic cells
Keywords: طرز تیروزین کیناز; Cholesterol crystals; Inflammation; Syk; PI3K; S100 proteins; CHC; cholesterol crystals; Syk; spleen tyrosine kinase; PI3K; phosphoinositide-3 kinase; MMP; matrix metalloprotease; NLRP3; Nod-like receptor related protein 3; DAMPs; damage associated molecu
Fifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseases
Keywords: طرز تیروزین کیناز; IgE; mast cells; anaphylaxis; ADAM; A disintegrin and metalloproteinase; AID; Activation-induced cytidine deaminase; APC; Antigen-presenting cell; BAFF; BÂ cell-activating factor of the TNF family; CSR; Class-switch recombination; DC; Dendritic cell; DS
Spleen Tyrosine Kinase Mediates EGFR Signaling to Regulate Keratinocyte Terminal Differentiation
Keywords: طرز تیروزین کیناز; ITAM; immunoreceptor tyrosine-based activation motif; NHEK; normal human epidermal keratinocytes; PMA; phorbol 12-myristate 13-acetate; siRNA; small interfering RNA; Syk; spleen tyrosine kinase; TGase; transglutaminase;
Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: Implications for disease pathogenesis and treatment
Keywords: طرز تیروزین کیناز; APRIL; a proliferation-inducing ligand; ATM; ataxia telangiectasia mutated; BAFF; B-cell activating factor; BAFFR; BAFF receptor; BAG6; BCL2-associated athanogene 6; BCMA; B-cell maturation antigen; BCL2; B-cell lymphoma 2; BCR; B cell receptor; bFGF; bas
C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits
Keywords: طرز تیروزین کیناز; Spleen Tyrosine Kinase; DNA Methylation; Tumor Suppressor; Inflammatory Homeostasis; CES; composite expression score; CLEC2; C-type lectin-like receptor 2; EMT; epithelial to mesenchymal transition; GSK3; glycogen synthase kinase 3; IHC; immunohistochemis
Therapeutic effects of resveratrol in a mouse model of HDM-induced allergic asthma
Keywords: طرز تیروزین کیناز; Syk; spleen tyrosine kinase; HDM; house dust mite; FcεR; Fcε receptor; DEX; dexamethasone; BAY; BAY 61-3606; BALF; bronchoalveolar lavage fluid; DMSO; dimethyl sulfoxide; RBL-2H3; rat basophilic leukemia cell; PBS; phosphate buffered physiological salin
Orally bioavailable Syk inhibitors with activity in a rat PK/PD model
Keywords: طرز تیروزین کیناز; Spleen Tyrosine Kinase; Fostamatinib; BIIB-057; GS-9973; Kinase inhibitors;
In vivo and in vitro anti-inflammatory activities of Persicaria chinensis methanolic extract targeting Src/Syk/NF-κB
Keywords: طرز تیروزین کیناز; Pc-ME; methanolic extract of Persicaria chinensis; HPLC; High performance liquid chromatography; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; TLR; Toll-like receptors (TLR); NF-κB; nuclear factor-κB; Akt; p
Hypermethylation in gastric cancer
Keywords: طرز تیروزین کیناز; 5-hmC; 5-hydroxymethylcytosine; 5-mC; 5-methylcytosine; ADAM23; ADAM metallopeptidase domain 23; APC; adenomatosis polyposis coli; ATP; adenosine-triphosphate; BCL6B; B-Cell CLL/Lymphoma 6, Member B; BGS; bisulfite genomic sequencing; BMP-2; bone morphoge
n-3 Polyunsaturated fatty acids inhibit Fc ε receptor I-mediated mast cell activation
Keywords: طرز تیروزین کیناز; AA; arachidonic acid; ANOVA; analysis of variance; β-hex; β-hexosaminidase; BMMC; bone marrow-derived mast cells; CCL2; chemokine (C-C motif) ligand 2; cys-LT; cysteinyl leukotrienes; DHA; docosahexaenoic acid; DNP; 2,4-dinitrophenol; DPA; docosapentaen
Activation of the NLRP3 inflammasome by vault nanoparticles expressing a chlamydial epitope
Keywords: طرز تیروزین کیناز; C. trachomatis; Chlamydia trachomatis; PmpG; polymorphic membrane protein G; CARD; caspase recruitment domain; MOMP; major outer membrane protein; PAMPs; pathogen associated molecular patterns; DAMPs; danger associated molecular patterns; NLR; Nod-like re
Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer
Keywords: طرز تیروزین کیناز; SYK; Spleen tyrosine kinase; Epithelial–mesenchymal transition; Protein phosphorylation; Signal transduction; Apoptosis
Signalling versatility following self and non-self sensing by myeloid C-type lectin receptors
Keywords: طرز تیروزین کیناز; Innate immunity; C-type lectin receptors; Myeloid cells; BDCA; blood DC antigen; CEACAM; carcinoembryonic antigen-related cell adhesion molecule; CLR; C-type lectin receptor; CTL; cytotoxic T lymphocyte; CTLD; C-type lectin domain; DAMP; damage-associated
Cell type-specific differences in β-glucan recognition and signalling in porcine innate immune cells
Keywords: طرز تیروزین کیناز; CR3; complement receptor 3; ROS; reactive oxygen species; FAK; focal adhesion kinase; Syk; spleen tyrosine kinase; MAMPs; microorganism-associated molecular patterns; DCs; dendritic cells; LAL; limulus amebocyte lysate; mAbs; monoclonal antibodies; MDM; m
CXCL12 and ADAM23 hypermethylation are associated with advanced breast cancers
Keywords: طرز تیروزین کیناز; ADAM23; disintegrin and metalloprotease domain 23; APC; adenomatous polyposis coli; BC; breast cancer; BRMS1; breast cancer metastasis suppressor 1; CDH1; cadherin 1, type 1; cfDNA; cell-free DNA; CMI; cumulative methylation index; CXCL12; chemokine C-X-C
Boerhavia diffusa L. ethanol extract suppresses inflammatory responses via inhibition of Src/Syk/TRAF6
Keywords: طرز تیروزین کیناز; Bd-EE; Boerhavia diffusa L. ethanol extract; HPLC; high performance liquid chromatography; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; TLR; Toll-like receptor (TLR); NF-κB; nuclear factor-κB; AP-1; Activat
Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors
Keywords: طرز تیروزین کیناز; Spleen tyrosine kinase; Pyrazolylpyrimidine; Syk inhibitors; Rheumatoid arthritis; Structure-activity relationship;
Syk inhibitors with high potency in presence of blood
Keywords: طرز تیروزین کیناز; Spleen tyrosine kinase; Aldehyde oxidase; Fostamatinib; BIIB-057; Kinase inhibitors
Myrsine seguinii ethanolic extract and its active component quercetin inhibit macrophage activation and peritonitis induced by LPS by targeting to Syk/Src/IRAK-1
Keywords: طرز تیروزین کیناز; Ms-EE; ethanolic extract of Myrsine seguinii; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumour necrosis factor; ERK; extracellular signal-related kinase; TLR; toll-like receptors (TLR); MAPK; mit
Insight into the therapeutic aspects of 'Zeta-Chain Associated Protein Kinase 70Â kDa' inhibitors: A review
Keywords: طرز تیروزین کیناز; Zeta-Chain Associated Protein Kinase 70Â kDa; T-cells; Spleen tyrosine kinase; Chronic lymphocytic leukemia;
Molecular targets on mast cells and basophils for novel therapies
Keywords: طرز تیروزین کیناز; Mast cell; basophil; mediator; receptor; signaling protein; survival protein; drug; therapy; BCL-2; B-cell lymphoma 2; BH; BCL-2 homology; Bs; Basophils; BTK; Bruton tyrosine kinase; CB; Endocannabinoid receptor; CRAC; Calcium release-activated calcium;