کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1392668 | 1501149 | 2013 | 6 صفحه PDF | دانلود رایگان |
• 6-Substituted 2-amino-4(3H)-pyrimidinone and 5-bromo derivatives are synthesized.
• The synthetic protocol is new and regioselective.
• Effect of structural variation at C-6 position on antiviral activity was evaluated.
• Some derivatives were active against various virus strains.
A series of 2-amino-5-bromo-4(3H)-pyrimidinone derivatives bearing different substituents at the C-6 position were synthesized using a highly regioselective lithiation–substitution protocol, and the effect of structural variation at the C-6 position on their antiviral activity in cell culture was evaluated. Although some of the derivatives were found to be active against various virus strains, they were effective only close to their toxicity threshold.
A series of 2-amino-5-bromo-4(3H)-pyrimidinone derivatives bearing different substituents at the C-6 position were synthesized using a versatile and efficient regioselective lithiation–substitution protocol and their antiviral activity was evaluated.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 67, September 2013, Pages 428–433