Drugs for stroke: Action of nitrone (Z)-N-(2-bromo-5-hydroxy-4-methoxybenzylidene)-2-methylpropan-2-amine oxide on rat cortical neurons in culture subjected to oxygen-glucose-deprivation

► RP6 is (Z)-N-(2-bromo-5-hydroxy-4-methoxybenzylidene)-2-methylpropan-2-amine oxide. ► The synthesis and neuroprotection properties of nitrone RP6 are described. ► RP6 protects cortical neurons against the ROS formation. ► RP6 protects cortical neurons against necrotic death and lipid peroxidation. ► RP6 is an attractive multipotent nitrone for stroke.