Quinazolino–benzothiazoles: Fused pharmacophores as anticonvulsant agents

A series of 6-bromo-2-ethyl-3-(substitutedbenzo[d]thiazol-2-yl)quinazolin-4(3H)-one 3 (a–j) were synthesized using appropriate synthetic route and evaluated experimentally by the Maximal Electro Shock (MES) and the PTZ-induced seizure methods. Among the tested compounds, 3-(benzo[d]thiazol-2-yl)-6-bromo-2-ethylquinazolin-4(3H)-one (3a) has shown significant activity against tonic seizure by the MES model and 6-bromo-2-ethyl-3-(6-methoxybenzo[d]thiazol-2-yl)quinazolin-4(3H)-one (3h) against clonic seizure by PTZ-induced seizure model. Not one of the selected compounds demonstrated any sign of neurotoxicity and hepatotoxicity.

In the present study synthesis and anticonvulsant activity of novel quinazolino–benzothiazoles were evaluated.Figure optionsDownload as PowerPoint slideHighlights
► Synthesis and anticonvulsant evaluation of 6-bromo-2-ethyl-3-(substitutedbenzo[d]thiazol-2-yl) quinazolin-4(3H)-one 3(a–j).
► Characterized by IR, 1H NMR, 13C NMR, FAB MASS technique.
► The title compound 3a and 3h shown promising anticonvulsant activity.