کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1393253 | 1501195 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and characterization of the Zn(II) and Cu(II) piperidinyl isoeuxanthone complexes: DNA-binding and cytotoxic activity
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Two new complexes, Zn(II) complex (1) and Cu(II) complex (2) with piperidinyl isoeuxanthone (1-hydroxy-6-(2-(1-piperidinyl)ethoxy)xanthone) have been synthesized and characterized. The interactions of them with calf thymus DNA (ct DNA) were investigated by absorption spectroscopy, fluorescence spectroscopy, ethidium bromide (EB) displacement experiments, circular dichroism (CD) spectroscopy and viscosity measurements. Experimental results indicated intercalative interaction with DNA for the complexes and the binding affinity of complex 2 is higher than that of 1. Moreover, the two complexes had potent cytotoxic activities toward three human cell lines, lung adenocarcinoma (GLC-82), esophagus squamous cancer (ECA109) and human gastric cancer (SGC7901) cells. The result of inhibitory effect in vitro is consistent with the result of DNA-binding studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 11, November 2009, Pages 4509-4515
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 11, November 2009, Pages 4509-4515
نویسندگان
Hui-Fang Wang, Rui Shen, Ning Tang,