کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1393340 | 1501203 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and antimalarial activity of pyrazolo and pyrimido benzothiazine dioxide derivatives
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and antimalarial activity of pyrazolo and pyrimido benzothiazine dioxide derivatives Synthesis and antimalarial activity of pyrazolo and pyrimido benzothiazine dioxide derivatives](/preview/png/1393340.png)
چکیده انگلیسی
A series of phenylsubstituted pyrazolo and pyrimido benzothiazine dioxide derivatives were synthesized and investigated for their abilities to inhibit β-hematin formation, hemoglobin hydrolysis and in vivo for their antimalarial efficacy in rodent Plasmodium berghei. The most active compound to emerge from the in vitro and in vivo murine studies was 2b, suggesting an antimalarial activity via inhibition of hemoglobin hydrolysis, however, not as efficient as chloroquine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 3, March 2009, Pages 1303-1310
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 3, March 2009, Pages 1303-1310
نویسندگان
Arthur Barazarte, Gricela Lobo, Neira Gamboa, Juan R. Rodrigues, Mario V. Capparelli, Ángel Álvarez-Larena, Simón E. López, Jaime E. Charris,