NSAIDs revisited: Putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARγ)

This paper describes molecular docking studies of a series of classical NSAIDs with PPARγ receptor, which has been pointed as a new target for the design of anti-cancer and anti-inflammatory drugs, and has been found to be responsible for some of the already established pharmacological effects observed for marketed drugs. The results show the molecular basis of PPARγ activation by non-selective COX inhibitors.

Figure optionsDownload as PowerPoint slide