کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1393445 1501211 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and antimicrobial activities of 7-O-modified genistein derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and antimicrobial activities of 7-O-modified genistein derivatives
چکیده انگلیسی

Three series of genistein derivatives with heterocycles were prepared, in which genistein and heterocyclic moieties were separated by 2-carbon, 3-carbon and 4-carbon spacers. Among the 33 compounds we prepared 11 of them (2c and 5a–j) are reported for the first time, while the preparation of 2a,b, 3a–j and 4a–j was reported in our recent paper. All the derivatives were screened for antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas fluorescence) and antifungal (Aspergillus niger, Candida albicans and Trichophyton rubrum) activities by MTT method. Among the compounds tested, 4a, 4e, 4f, 4h, 5e and 5f exhibited good antibacterial activities while 4a also showed notable antifungal activity. Especially, 5f exhibited stronger antibacterial activity against B. subtilis and S. aureus comparable to positive controls.

Three series of genistein derivatives were synthesized and evaluated for antibacterial and antifungal activities by MTT method. Compound 5f exhibited the strongest antibacterial activity against Bacillus subtilis and Staphylococcus aureus comparable to positive controlsFigure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 43, Issue 7, July 2008, Pages 1543–1551
نویسندگان
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