Chemotherapy of leishmaniasis. Part V: Synthesis and in vitro bioevaluation of novel pyridinone derivatives

Some novel 2-substituted pyridinone derivatives exemplified by 3 and 4 have been synthesized from 2-methyl-γ-pyrone and screened towards in vitro antileishmanial activity profile. Some of the compounds such as 3a, 3b, 4i and 4j displayed good antileishmanial profile.

Some novel substituted pyridinone derivatives have been synthesized from 2-methyl-γ-pyrone showed good antileishmanial profile.Figure optionsDownload as PowerPoint slide