کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1393806 | 1501103 | 2016 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives](/preview/png/1393806.png)
چکیده انگلیسی
Extending the anilinophthalazine derivatives 4 with a substituted phenyl moiety through an uriedo linker increased the hydrophobic interaction of uriedo-anilinophthalazine derivatives 7 within the hydrophobic back pocket.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 113, 4 May 2016, Pages 50-62
Journal: European Journal of Medicinal Chemistry - Volume 113, 4 May 2016, Pages 50-62
نویسندگان
Wagdy M. Eldehna, Sahar M. Abou-Seri, Ahmed M. El Kerdawy, Rezk R. Ayyad, Abdallah M. Hamdy, Hazem A. Ghabbour, Mamdouh M. Ali, Dalal A. Abou El Ella,