Keywords: QDTMDJFGPYPXBK-VQGHGNOBSA-N; 4,6-Diaryl-2-pyrimidinamine derivatives; Anti-breast cancer; SERMs; VEGFR-2;
مقالات ISI (ترجمه نشده)
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Keywords: Dihydropyrimidinone; Anticancer; mTOR; VEGFR-2; Cell cycle analysis; Apoptosis;
Keywords: Diabetic foot ulcers; Electrical stimulation; VEGF; HIF-1α; NO; VEGFR-2;
Keywords: 7AAD; 7-aminoactinomycin D; αSMA; alpha smooth muscle actin; AKT; protein kinase B; ALK; activin receptor-like kinase; Ang; angiopoietin; Ang II; angiotensin II; BCRP1; breakpoint cluster region pseudogene; bFGF; basic fibroblast growth factor; C1P; cera
Keywords: HDO; heparin, derived oligosaccharide; MTT; methyl thiazolyl tetrazolium; VEGF; vascular endothelial growth factor; VSMC; vascular smooth muscle cell; VEGFR-1; vascular endothelial growth factor receptor 1; VEGFR-2; vascular endothelial growth factor rece
Keywords: Pancreatic cancer; Angiogenesis; Vascular endothelial growth factor (VEGF); ANGPT; angiopoietin; BRAF; serine/threonine-protein kinase B-raf; CAF; cancer associated fibroblast; Cdkn2a; cyclin-dependent kinase inhibitor 2A; CI; confidence interval; CSF1R;
Keywords: Marmesin; Angiogenesis inhibitor; Vascular endothelial growth factor; VEGFR-2; β1 integrin;
Keywords: Copper; Cardiac hypertrophy; CCO; Angiogenesis; VEGFRs; HIF-1; ANG-1; angiopoietin-1; ANG-2; angiopoietin-2; ANP; atrial natriuretic peptide; ATOX1; antioxidant 1; ATP; adenosine triphosphate; BNP; B-type natriuretic peptide; BNIP3; BCL2/adenovirus E1B 19
Keywords: VEGFR-2; vascular endothelial growth factor receptor-2; CXCR4; C-X-C chemokine receptor type 4; TGF-β1; transforming growth factor beta 1; Smad2/3; mothers against decapentaplegic homolog 2/3; p38MAPK; p38 mitogen-activated protein kinases; ERK1/2; extra
Design, synthesis and preclinical evaluation of 5-methyl-N4-aryl-furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential
Keywords: RTKs; Receptor tyrosine kinases; VEGF; vascular endothelial growth factor; VEGFR-2; vascular endothelial growth factor receptor-2; PDGFR-β; platelet-derived growth factor receptor-β; EGFR; epidermal growth factor receptor; ATP; adenosine triphosphate; N
A Vascular Endothelial Growth Factor-Dependent Sprouting Angiogenesis Assay Based on an In Vitro Human Blood Vessel Model for the Study of Anti-Angiogenic Drugs
Keywords: Angiogenesis inhibitors; DLL4; Human umbilical vein endothelial cell; In vitro 3D model; Microvessel; Notch; Sorafenib; Sprouting angiogenesis; Sunitinib; Vascular endothelial growth factor; 3D; three-dimensional; BSA; bovine serum albumin; CLSM; confocal
Design and discovery of thioether and nicotinamide containing sorafenib analogues as multikinase inhibitors targeting B-Raf, B-RafV600E and VEGFR-2
Keywords: Nicotinamide; B-Raf; VEGFR-2; Kinase inhibitor; Antitumor;
VEGFR-2 as a novel predictor of survival in gastric cancer: A systematic review and meta-analysisâ¨
Keywords: Gastric cancer; VEGFR-2; Meta-analysisâ¨;
Computational design and experimental characterization of a novel β-common receptor inhibitory peptide
Keywords: EPO; erythropoietin; βCR; beta common receptor; IL; interleukin; GM-CSF; graulocyte macrophage colony stimulating factor; JAK; janus kinase; STAT; signal transducer and activator of transcription; MAPK; mitogen-activated protein kinase; PI3K; phosphatidy
Branched pentapeptides as potent inhibitors of the vascular endothelial growth factor 165 binding to Neuropilin-1: Design, synthesis and biological activity
Keywords: Neuropilin-1; VEGF165; Neuropilin/VEGF165 binding inhibition; Structure-activity relationship; Peptide biostability; ABTS; 2,2â²-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt; Ahp; 7-aminoheptanoic acid; Aun; 11-aminoundecanoic acid;
Structure-activity relationships of 2, 4-disubstituted pyrimidines as dual ERα/VEGFR-2 ligands with anti-breast cancer activity
Keywords: 2, 4-disubstituted pyrimidines; ERα; VEGFR-2; Antiangiogenesis; Anti-Breast cancer;
Design, synthesis, biological evaluation and molecular modeling of novel 1H-pyrazolo[3,4-d]pyrimidine derivatives as BRAFV600E and VEGFR-2 dual inhibitors
Keywords: Dual inhibitor; BRAFV600E; VEGFR-2; 1H-pyrazolo[3,4-d]pyrimidine; Tyrosine kinase;
Design, synthesis, and biological evaluation of thieno[2,3-d]pyrimidine derivatives as novel dual c-Met and VEGFR-2 kinase inhibitors
Keywords: c-Met; VEGFR-2; Kinase; Thieno[2,3-d]pyrimidine; Cancer;
Discovery of novel 2-substituted-4-(2-fluorophenoxy) pyridine derivatives possessing pyrazolone and triazole moieties as dual c-Met/VEGFR-2 receptor tyrosine kinase inhibitors
Keywords: c-Met; VEGFR-2; 2-Substituted-4-(2-fluorophenoxy) pyridine; Pyrazolone; Triazole;
Naringin promotes fracture healing through stimulation of angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats
Keywords: Angiogenesis; Naringin; VEGF; VEGFR-2;
TNF-α upregulates HIF-1α expression in pterygium fibroblasts and enhances their susceptibility to VEGF independent of hypoxia
Keywords: Pterygium fibroblast; TNF-α; HIF-1α; VEGF-A; VEGFR-2;
Pyrimidinylacetamide-based 2-pyridylureas as Angiogenesis Inhibitors: Design, Synthesis and Biological Evaluation
Keywords: Pyrimidinylacetamide; Ureas; VEGFR-2; Anti-proliferative activity; Anti-angiogenesis;
Design and discovery of 4-anilinoquinazoline-urea derivatives as dual TK inhibitors of EGFR and VEGFR-2
Keywords: 4-Anilinoquinazoline-urea; EGFR; VEGFR-2; Tyrosine kinase inhibitor; Antitumor;
Design, synthesis, molecular docking and cytotoxic evaluation of novel 2-furybenzimidazoles as VEGFR-2 inhibitors
Keywords: Angiogenesis; VEGFR-2; 2-Furylbenzimidazole; MCF-7; HepG2;
Design, synthesis and biological evaluation of biphenylurea derivatives as VEGFR-2 kinase inhibitors (II)
Keywords: Angiogenesis; Kinase; Inhibitor; VEGFR-2
Ranibizumab interacts with the VEGF-A/VEGFR-2 signaling pathway in human RPE cells at different levels
Keywords: VEGF-A; vascular endothelial growth factor A; VEGFR-2; vascular endothelial growth factor receptor 2; RPE; retinal pigment epithelium; AMD; age-related macular degeneration; Ranibizumab; RPE; VEGF-A; VEGFR-2; Oxidative stress;
Emerging roles of the acute phase protein pentraxin-3 during central nervous system disorders
Keywords: Aβ; amyloid-β; AD; Alzheimer's disease; APPs; acute phase proteins; APR; acute phase response; BBB; blood-brain barrier; C1q; complement component 1q; CNS; central nervous system; CRP; C-reactive protein; CSF; cerebral spinal fluid; DCs; dendritic cel
Original ArticleImmunology/InfectionEarly Tumor-Infiltrating Dendritic Cells Change their Characteristics Drastically in Association with Murine Melanoma Progression
Keywords: CFSE; carboxyfluorescein succinimidyl ester; DCs; dendritic cells; LNs; lymph nodes; PD-L1; programmed death-ligand 1; rDCs; resident DCs; TIDCs; tumor-infiltrating dendritic cells; VEGFR-2; vascular endothelial growth factor receptor 2;
Design and discovery of 4-anilinoquinazoline-acylamino derivatives as EGFR and VEGFR-2 dual TK inhibitors
Keywords: 4-Anilinoquinazoline-acylamino; EGFR; VEGFR-2; Tyrosine kinase inhibitor; Antitumor
Ramucirumab With Eribulin Versus Eribulin in Locally Recurrent or Metastatic Breast Cancer Previously Treated With Anthracycline and Taxane Therapy: A Multicenter, Randomized, Phase II Study
Keywords: Antiangiogenic therapy; Brain metastasis; Targeted agents; Triple-negative status; VEGFR-2;
Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC
Keywords: N-Phenylquinazolin-4-amine hybrid; VEGFR-2; HDAC; Dual inhibitor
Downregulation of Syndecan-1 induce glomerular endothelial cell dysfunction through modulating internalization of VEGFR-2
Keywords: AKI; acute kidney injury; GEnC; glomerular endothelial cells; HSPG; heparan sulfate proteoglycan; Syndecan-1; VEGFR-2; Glomerular endothelial cell; Injury;
Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives
Keywords: Phthalazine; VEGFR-2; Hydrophobic interaction;
Design, synthesis and biological evaluation of 4-aminopyrimidine-5-cabaldehyde oximes as dual inhibitors of c-Met and VEGFR-2
Keywords: Oxime; c-Met; VEGFR-2; Synergistically collaborate; Cancers;
Associate editor: B. PatelAntagonist antibodies to vascular endothelial growth factor receptor 2 (VEGFR-2) as anti-angiogenic agents
Keywords: Tumor vasculature; Angiogenesis; Endothelial cell; VEGFR-2; Ramucirumab; DC101; Ang1; angiopoietin 1; Ang2; angiopoietin 2; bFGF; basic fibroblast growth factor; CEP; circulating endothelial progenitor cells; DCE-CT; dynamic contrast-enhanced computerized
Identification of new potent phthalazine derivatives with VEGFR-2 and EGFR kinase inhibitory activity
Keywords: Phthalazine; Cytotoxicity; VEGFR-2; EGFR; Docking;
Design, synthesis and biological evaluation of O-linked indoles as VEGFR-2 kinase inhibitors (I)
Keywords: VEGFR-2; Inhibitor; Indole
Expression and prognostic significance of VEGFR-2 in breast cancer
Keywords: Breast cancer; VEGFR-2; Epithelial-mesenchymal transition (EMT); Metastasis
The unbinding studies of vascular endothelial growth factor receptor-2 protein tyrosine kinase type II inhibitors
Keywords: VEGFR-2; SMD; Fragment build; Pull force; Electrostatic interaction
Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase
Keywords: Hybrid; 4-Anilinoquinazoline; Hydroxamic acid; VEGFR-2; HDAC;
Discovery of novel VEGFR-2 inhibitors. Part II: Biphenyl urea incorporated with salicylaldoxime
Keywords: VEGFR-2; Biphenyl urea; Intramolecular hydrogen bond; Salicylaldoxime
Anti-psoriatic effects of Honokiol through the inhibition of NF-κB and VEGFR-2 in animal model of K14-VEGF transgenic mouse
Keywords: Honokiol; Psoriasis; K14-VEGF; NF-κB; VEGFR-2
Indoline ureas as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro biological evaluation and molecular docking
Keywords: Design; HepG2; Urea; VEGFR-2; DockingBWDUFTFGRLWGPS-UHFFFAOYSA-N; RJXKVRUPSNTEFX-UHFFFAOYSA-N; OKLQCYFQMONOPW-UHFFFAOYSA-N; DNZXILGNPOQNRU-UHFFFAOYSA-N; UVYSLYUGYAMGFT-UHFFFAOYSA-N; WJTWGCCKHAGBQI-UHFFFAOYSA-N; AFQLIQQRPCOQKP-UHFFFAOYSA-N; LVOLDCCULPVRSN-
Molecular dynamics simulation and free energy calculation studies of kinase inhibitors binding to active and inactive conformations of VEGFR-2
Keywords: VEGFR-2; Type I inhibitors; Type II inhibitors; Molecular dynamics; MM-PBSA; MM-GBSA
Novel zinc finger transcription factor ZFP580 promotes differentiation of bone marrow-derived endothelial progenitor cells into endothelial cells via eNOS/NO pathway
Keywords: bFGF; recombinant rat basic fibroblast growth factor; C2H2; Cys2-His2; DiL-ac-LDL; Dil-conjugated acetylated low-density lipoprotein; ECs; endothelial cells; eNOS; endothelial nitric oxide synthase; EPCs; endothelial progenitor cells; FACS; fluorescence
Discovery of novel tricyclic pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-amine derivatives as VEGFR-2 inhibitors
Keywords: Pyridothienopyrimidine; Kinase; VEGFR-2; Inhibitors; Docking studies
Rapid modification of the bone microenvironment following short-term treatment with Cabozantinib in vivo
Keywords: CBZ; Cabozantinib; GFP Ob+; green fluorescent protein expressing cells of the osteoblastic lineage; CTRL; control; PBS; phosphate buffered saline; TRAP; tartrate resistant alkaline phosphatase; PINP; procollagen type 1 N-terminal propeptide; MET; hepatocy
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents
Keywords: CA-4P; combretastatin A-4 phosphate; VEGFR-2; vascular endothelial growth factor receptor-2; RTKs; receptor tyrosine kinases; 2ME2; 2-methoxyestradiol; PDGFR-β; platelet-derived growth factor receptor β; CAM; chorioallantoic membrane; DDQ; 2,3-dichloro-
Synthesis and biological evaluation of 2,3-diaryl isoquinolinone derivatives as anti-breast cancer agents targeting ERα and VEGFR-2
Keywords: ONQWDYUQNJQOHX-UHFFFAOYSA-N; NBGMIOBNSRVIGS-UHFFFAOYSA-N; KOLLDFQDXJDDRF-UHFFFAOYSA-N; 2,3-Diaryl isoquinolinone derivatives; Synthesis; Anti-breast cancer; ERα; VEGFR-2;
Suppression of alpha-tocopherol ether-linked acetic acid in VEGF-induced angiogenesis and the possible mechanisms in human umbilical vein endothelial cells
Keywords: EC; endothelial cell; ECGS; endothelial cell growth supplement; ELISA; enzyme-linked immunosorbent assay; FAK; focal adhesion kinase; FBS; fetal bovine serum; HUVECs; human umbilical vein endothelial cells; MMPs; matrix metalloproteinases; VEGF; vascular