Design, synthesis and biological evaluation of 4-aminopyrimidine-5-cabaldehyde oximes as dual inhibitors of c-Met and VEGFR-2

The cyclopropane-1,1-dicarboxamide moiety might be critical for the potent dual inhibition of c-Met and VEGFR-2. 4-Aminopyrimidine-5-cabaldehyde oxime as the scaffold of potent VEGFR-2 inhibitor was combined with the cyclopropane-1,1-dicarboxamide moiety to obtain potent c-Met and VEGFR-2 inhibitor.