Pyrimidinylacetamide-based 2-pyridylureas as Angiogenesis Inhibitors: Design, Synthesis and Biological Evaluation

In HUVEC inhibition assay, the most potent compound (compound 16) possessed an IC50 value of 0.43 μM. Compound 16 also inhibited the migration and capillary like tube formation of HUVECs with inhibition rate at 22% (1 μM) and 17.5% (0.8 μM) respectively. These results support the further investigation of compound 16 as a potential anti-cancer agent.