Synthesis and anticancer activity of new dihydropyrimidinone derivatives

A series of dihydropyrimidinone derivatives bearing various heteroaryl moieties was designed, synthesized and evaluated for anticancer activity. Compound 19 possessed the most significant activity against NCI-H460, SK-MEL-5 and HL-60 (TB) cell lines. It proved to have dual inhibitory effect against VEGFR-2 and m TOR. Cell cycle analysis of A549 cells showed cell cycle arrest at G2/M phase and pro-apoptotic activity.177