کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1394032 1501124 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and antifungal activity of novel streptochlorin analogues
ترجمه فارسی عنوان
سنتز و فعالیت ضد قارچی آنالوگهای استرپتوکلورین جدید
کلمات کلیدی
استرپتوکلورین، محصول طبیعی، فعالیت ضد قارچی، سنتز، روابط ساختاری-فعالیت
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی


• A series of novel indole-modified analogues of streptochlorin were synthesized.
• Streptochlorin analogues were screened against seven phytopathogenic fungi.
• Some compounds showed good antifungal activity in primary assays.
• The SAR of the streptochlorin analogues were summarized.

Streptochlorin, first isolated as a new antibiotic in 1988 from the lipophilic extracts of the mycelium of a Streptomyces sp, is an indole natural products with a variety of biological activities. Based on the methods developed for the synthesis of pimprinine in our laboratory, we have synthesized a series of indole-modified streptochlorin analogues and measured their activities against seven phytopathogenic fungi. Some of the analogues displayed good activity in the primary assays, and the seven compounds 10b, 10c, 11e, 13e, 21, 22c and 22e (shown in Figure 1) were identified as the most promising candidates for further study. Structural optimization is still ongoing with the aim of discovering synthetic analogues with improved antifungal activity.

A series of novel streptochlorin analogues were designed and synthesized by modifying the indole moiety. Antifungal activity screening against seven phytopathogenic fungi led to the identification of seven compounds as the most promising candidate for further study.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 92, 6 March 2015, Pages 776–783
نویسندگان
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