Synthesis, characterization and cytotoxicity of platinum(II)/palladium(II) complexes with 1,3-diaminopropane and 4-toluensulfonyl-l-amino acid dianion

Eight novel platinum(II)/palladium(II) complexes with 1,3-dap and 4-toluensulfonyl-l-amino acid dianion, [Pt(1,3-dap)(TsalaNO)]·0.5H2O (1a), [Pt(1,3-dap)(TsvalNO)] (1b), [Pt(1,3-dap)(TspheNO)] (1c), [Pt(1,3-dap)(TsserNO)] (1d), [Pd(1,3-dap)(TsalaNO)]·1.5H2O (2a), [Pd(1,3-dap)(TsvalNO)] (2b), [Pd(1,3-dap)(TspheNO)] (2c) and [Pd(1,3-dap)(TsileNO)] (2d) have been synthesized and characterized by elemental analysis, IR, UV, 1H NMR and mass spectrometry techniques. Crystal structure of the complex 1b has been determined by X-ray diffraction. The cytotoxicity was tested by MTT and SRB assays. The complexes (1a–1d and 2a–2d) exert cytotoxicity against Bel-7402, HL-60, KB and BGC-823, but none of them is more active than cisplatin. The results suggest that metal ions, amino acids and aliphatic N-containing ligands have effect on cytotoxicity, while the IC50 values do not show definite correlation with variation of them.

Eight new platinum(II)/palladium(II) complexes have been synthesized. Crystal structure of complex 1b has been determined by X-ray diffraction analysis. The cytotoxicity was tested by MTT and SRB assays.Figure optionsDownload as PowerPoint slideHighlights
► Eight platinum(II)/palladium(II) complexes have been synthesized.
► Crystal structure of the complex 1b has been determined.
► The most complexes exert cytotoxic effects with selectivity.
► Amino acids, N-containing ligands and metal ions have effect on cytotoxicity.